Relevance of Biofilm Models in Periodontal Research: From Static to Dynamic Systems

Microbial biofilm modeling has improved in sophistication and scope, although only a limited number of standardized protocols are available. This review presents an example model, along with its evolution application studying periodontal peri-implant diseases. In 2011, the ETEP (Etiology Therapy Periodontal Peri-Implant Diseases) research group at University Complutense Madrid developed vitro static model using representative bacteria from subgingival microbiota, demonstrating pattern bacterial colonization maturation similar to vivo biofilms. When methodology were standardized, employed validated for testing different applications. The this is described manuscript, mere observation growth on models hydroxyapatite or titanium discs, evaluation impact dental implant surface composition micro-structure dynamic model. was based reproducing ideal microenvironmental conditions within bioreactor reaching target surfaces fluid dynamics mimicking salivary flow. development relevant become powerful tool study essential processes that regulate formation these important microbial communities, as well their behavior when exposed antimicrobial compounds.